Polarized Molecular Orbital Model Chemistry. 2. The PMO Method

Molecular orbital methods in organic chemistry

Application of the PMO-Method to the Chemistry of Cyclopropane and Cyclobutane

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Using the fragment molecular orbital method to investigate agonist–orexin-2 receptor interactions

The understanding of binding interactions between any protein and a small molecule plays a key role in the rationalization of affinity and selectivity and is essential for an efficient structure-based drug discovery (SBDD) process. Clearly, to begin SBDD, a structure is needed, and although there has been fantastic progress in solving G-protein-coupled receptor (GPCR) crystal structures, the pr...

Prediction of cyclin-dependent kinase 2 inhibitor potency using the fragment molecular orbital method

BACKGROUND The reliable and robust estimation of ligand binding affinity continues to be a challenge in drug design. Many current methods rely on molecular mechanics (MM) calculations which do not fully explain complex molecular interactions. Full quantum mechanical (QM) computation of the electronic state of protein-ligand complexes has recently become possible by the latest advances in the de...

Open-Shell Formulation of the Fragment Molecular Orbital Method.

Performing accurate calculations on large molecular systems is desirable for closed- and open-shell systems. In this work, the fragment molecular orbital method is extended to open-shell systems and implemented in the GAMESS (General Atomic and Molecular Electronic Structure System) program package. The accuracy of the method is tested, and the ability to reproduce reaction enthalpies is demons...